My computer still has the 100% disk problem, however it seems to happen less by following the steps below:

  1. Disable Windows Search, Superfetch.
  2. Disable Virus & threat protection in Windows Defender Security Center.
  3. Create a High Performance power plan.
  4. Update your drivers Can be done automatically by using Driver Booster 6.
  5. Give Skype write permission.
  6. Clear out disk spaces.

Further Reading

  1. Windows 10 100% disk usage in Task Manager [SOLVED] | Driver Easy